The primary and most active ingredient in Malegra tablets is sildenafil citrate, which works as an inhibitor of the cGMP-specific phosphodiesterase type-5 (PDE-5) enzyme. This enzyme aids in smooth muscle relaxation by breaking down cGMP.

The smooth muscles' cGMP levels rise when the PDE-5 is inhibited, which causes the muscles to relax and the blood vessels to dilate, or widen.

Since sildenafil is so well-known for being a PDE-5 inhibitor, the Malegra tablets also belong to this class.

Taking the Malegra 100 tablets aids in the treatment of pulmonary arterial hypertension (PAH) because PDE-5 is also found in the lungs.